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Canadian residents ought to simply call their regional poison Command Centre directly. Indications of overdose may perhaps involve excessive drowsiness; gradual, shallow breathing; unexpected onset of perspiring; pale pores and skin; blurred eyesight; and lack of consciousness.

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Diazepam and its metabolites are extremely certain to plasma proteins (diazepam 98%). Diazepam and its metabolites cross the blood-brain and placental boundaries and also are present in breast milk in concentrations about one tenth of These in maternal plasma (times three to nine write-up-partum).

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Skipped DOSE: Just take your dose at or near bedtime. In case you skip a dose, do not take if near the time for the subsequent dose. Instead, skip the skipped dose and resume your normal dosing agenda. Never "double-up" the dose to catch up.

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Even though the specific mechanism by which diazepam exerts its antiseizure effects is unidentified, animal As well as in vitro scientific tests recommend that diazepam functions to suppress seizures as a result of an conversation with gamma-aminobutyric acid (GABA) receptors from the A-type (GABAA). GABA, the most important inhibitory neurotransmitter from the central nervous process, acts at this receptor to open up the membrane channel allowing chloride ions to stream into neurons.